NMR analysis of protein interactions
نویسندگان
چکیده
منابع مشابه
Nmr Analysis of Protein-small Molecule Interactions
INTRODUCTION Advances in NMR technology over the last 20 years have made information on solution structures of proteins increasingly available. High-resolution solution structures of proteins as large as 20-25 kDa are tractable in most cases, and recent advances allowed Kay to solve the structure of an 82 kDa protein. These advances in NMR analysis of protein structure have made possible the st...
متن کاملThe structural analysis of protein-protein interactions by NMR spectroscopy.
A comprehensive understanding of protein-protein interactions is an important next step in our quest to understand how the information contained in a genome is put into action. Although a number of experimental techniques can report on the existence of a protein- protein interaction, very few can provide detailed structural information. NMR spectroscopy is one of these, and in recent years seve...
متن کاملQuantitative analysis of protein-ligand interactions by NMR.
Protein-ligand interactions have been commonly studied through static structures of the protein-ligand complex. Recently, however, there has been increasing interest in investigating the dynamics of protein-ligand interactions both for fundamental understanding of the underlying mechanisms and for drug development. NMR is a versatile and powerful tool, especially because it provides site-specif...
متن کاملStudies of protein-ligand interactions by NMR.
Solution-state NMR has become an accepted method for studying the structure of small proteins in solution. This has resulted in over 3000 NMR-based co-ordinate sets being deposited in the Protein Databank. It is becoming increasingly apparent, however, that NMR is also a very powerful tool for accessing interactions between macromolecules and various ligands. These interactions can be assessed ...
متن کامل(S)Pinning down protein interactions by NMR
Protein molecules are highly diverse communication platforms and their interaction repertoire stretches from atoms over small molecules such as sugars and lipids to macromolecules. An important route to understanding molecular communication is to quantitatively describe their interactions. These types of analyses determine the amounts and proportions of individual constituents that participate ...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2005
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2005.08.011